customized packing available

 

Seramectin (also known as siramectin) is fermented by a new strain of Streptomyces avermitilis. Abamectins are a group of macrolide drugs produced by the fermentation of Streptomyces. Effectively control agricultural pests and a variety of harmful mites, especially those that are resistant to commonly used pesticides and have excellent control effects. It is relatively safe for crops and will not kill natural enemies, which is conducive to ecological balance. At the same time, avermectin drugs have a strong repellent effect on human and animal parasitic nematodes and arthropod parasites, and have the advantages of broad spectrum, high efficiency and low toxicity. They are used in the prevention and control of animal and human parasites. Very extensive.

 

The mechanism of action of selamectin

The mechanism of action of seramectin is the same as that of other abamectin drugs. On the one hand, it can act as a gamma-aminobutyric acid (GABA) agonist to trigger the release of presynaptic GABA, which in turn causes the membrane permeability to Cl¯ On the other hand, the drug can open the chloride channel controlled by glutamate, increase the permeability of Cl¯ and cause hyperpolarization of the membrane potential, thereby blocking the conduction of nerve signals, causing rapid, lethal and non-infectious parasites. Death due to spastic neuromuscular paralysis. Because flukes and tapeworms do not have Cl¯ channels controlled by GABA neurotransmitters and glutamate, these drugs have no repellent effect on them. The drug binding site of invertebrates is in the peripheral tissues, while the drug binding site of mammals is in the central nervous system. Due to the action of the blood-brain barrier, these drugs rarely enter the brain tissue. Therefore, these drugs are effective for most mammals. Animals are safe. Collie dogs are sensitive to most abamectin drugs, but there are reports that seramectin is safe for Collie dogs.

 

The chemical properties of selamectin

English name: Selamectin

Molecular formula: C43H63NO11

Molecular weight: 769.967

Boiling point: 917.0±65.0°C

Density: 1.35±0.1g/cm3

Storage conditions: 2-8°C

Acidity coefficient (pKa): Chemicalbook 10.34±0.70

CAS No.: 220119-17-5

 

 

Most of our products have 2 years shelf life, during the shelf life, the products are guaranteed by our company. We have hassle free return policy. If the products do not meet your requirement, we will offer a refund according to the quantity of the products that are returned. 

If you need more details about this product or request a sample, please contact our online customer service or send us an email.

NOTICE: We have more than 2,000 kinds of products, and not all of them are listed on our website. Please contact us if you can not find it on our site

 

 

Repellent activity

1. Repellent effect on mites

Seramectin has a good repellent effect on mites. Studies have shown that topical seramectin at a dose of 6.0~11.0 mg/kg has a cure rate of 100% for dog scabies mites; in addition, it can also kill the infected mites of rabbits, mice and ferrets. Effectively, seramycin (6.0~18.0 mg/kg) was applied topically to 48 rabbits infected with itchy ear mites. After 56 days of treatment, the ear itch mites were 100% repelled; 10.0~12.4 mg/ The efficacy of seramectin was observed on mice infected with mites at a dose of kg. The mites were 100% repelled after 7 days of treatment; in addition, the repelling rate of the itch mites naturally infected by ferrets reached 100%.

 

2. Repelling effect of fleas

Seramectin also has a good repellent effect on infected fleas in dogs and cats. Studies have shown that among a series of derivatives of monosaccharide C 5-oximino abamectin, the highest killing activity against cat fleas (Ctenocephalus spp.) is selamectin, which has the smallest detectable concentration The value of (MDD) is 0.1μg/mL, and the safety to humans and animals is also significantly improved; gestational beagles infected with Ctenocephalus cats were treated with seramycin (6.0 mg/kg) before and after delivery. The infection rate of Ctenocephalus in puppies and cats was 99.8% and 100% lower than that of the blank control group; seramycin was used for dogs (362) and cats (276) at a dose of 6.0 mg/kg, and the drug was found for 30 days Later, the killing rate of cat and dog Ctenocephalus both reached more than 90%.

 

3. Repellent effect on lice

The study found that topical seramectin (6.0 mg/kg) has a 100% repellent rate for dogs (20) and cats (18); seramectin is used to treat dogs at a dose of 7.9 mg/kg (10) of spinach lice infection, the reduction of spinach lice in the treatment group after 42 days of treatment was significantly different from that of the blank control group. In addition, in Germany, seramectin has also been used to treat bald eagle lice infection in clinical cases.

 

4. Repellent effect on ticks

Seramectin (6.0 mg/kg) was used weekly to test dogs infected with Rhipicephalus sanguineus and Dermacentor variabilis. It was found that the number of infected ticks in the test group was significantly lower than that in the control group after 5 days of treatment. The blood sucking volume of Dermatophaga variabilis was also significantly reduced; after 21 days of treatment, the killing rate of Rhipicephalus sanguineus was 100%, and that of Dermatophaga mutans was greater than 96%.

 

5. Preventive effect on heartworm in dogs

Seramectin can effectively prevent heartworm infection in dogs. During the heartworm infection season (May-November), 388 dogs in Italy and the United States who are susceptible to heartworm infection were given topical topical seramycin (6.0 mg/kg) every month. After checking the antigens of microfilaria and adult worms for 300 days, it was found that the prevention rate of seramectin against heartworm canines reached 100%; seramectin also has a good effect on preventing cats from being infected with heartworm canis. Some scholars have reported that, Seramectin was administered to 158 cats at a dose of 6.0 mg/kg every month for 6 to 7 months, and it was found that the prevention rate against heartworm canines was 100%.

 

6. Repelling effect on other nematodes

Studies have shown that the monthly use of seramectin at a dose of 6.0 mg/kg has a good effect on the treatment of toxoplasma infections in pregnant and lactating dogs and newborn puppies; it has a good effect on 30 puppies (2 to 3 months). Age) topical seramycin 6.0 mg/kg for 1 month, the result is that the Toxoplasma canis eggs in the pup’s feces decreased by more than 90%; in the United States, France, Germany and Italy, the seramycin transdermal agent was used to treat domestic cats. The curative effects of roundworms and hookworms were tested, and it was found that on the 30th and 60th days after administration, the roundworm eggs in the feces were reduced by 96.5% and 99.9%, and the hookworm eggs were reduced by 98.3% and 100%, respectively.